HCID 53739287, compound → HCID 54124626, compound

Participants

Reaction Steps

9 g (19.9 mmol) of (S)-12,12a-dihydro-1-(3-phthalimidomethyl-1,2,4-oxadiazol-5-yl)-9H,11H-azeto[2,1-c]imidazo[1,5-a][1,4]benzodiazepin-9-one in 20 ml of ethanol and 65 ml of methylamine (33%) in ethanol were stirred at 70° for 2 hours. The solution was concentrated and the residue was triturated with 70 ml of methylene chloride. The suspension obtained was filtered. After drying the filter residue there was obtained (S)-1-(3-aminomethyl-1,2,4-oxadiazol-5-yl)-12,12a-dihydro-9H,11H-azeto[2,1-c]imidazo[1,5-a][1,4]benzodiazepin-9-one, which was used without further crystallization as the starting material for the Example described hereinafter.

Provenance & Evidence