Allyl bromide → HCID 22914325, compound

Participants

Reaction Steps

1.5 g (4.4 mmol) of 3-(5-aminomethyl-1,2,4-oxadiazol-3-yl)-7-chloro-5,6-dihydro-5-methyl-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one, 20 ml of N,N-dimethylformamide, 210 ml (12 mmol) of N-ethyldiisopropylamine and 1.16 g (9.6 mmol) of allyl bromide were stirred at room temperature for 4 hours. The reaction solution was evaporated and the residue was chromatographed on 250 g of silica gel while eluting with ethyl acetate. The uniform fractions were evaporated. There were obtained 1.54 g (82%) of 3-(5-diallylaminomethyl-1,2,4-oxadiazol-3-yl)-7-chloro-5,6-dihydro-5-methyl-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one, which was converted into the hydrochloride of m.p. 126°-130°.

Provenance & Evidence