6-[4-(3-aminopropoxy)-3-chloro-phenyl]-4,5-dihydro-3(2H)-pyridazinone → 6-[4-[3-[3-(4-(2-Isopropoxyethoxy-methyl)phenoxy)-2-hydroxypropylamino]propoxy]-3-chloro-phenyl]-4,5-dihydro-3(2H)-pyridazinone

HRID 137805Notes

Reaction equation

HRID 137805 reaction equation
[CH:1]([CH3:2])([CH3:3])[O:4][CH2:5][CH2:6][O:7][CH2:8][c:9]1[cH:10][cH:11][c:12]([O:13][CH2:14][CH:15]2[CH2:16][O:17]2)[cH:18][cH:19]1.[NH2:20][CH2:21][CH2:22][CH2:23][O:24][c:25]1[c:26]([Cl:38])[cH:27][c:28]([C:31]2=[N:36][NH:35][C:34](=[O:37])[CH2:33][CH2:32]2)[cH:29][cH:30]1>>[CH:1]([CH3:2])([CH3:3])[O:4][CH2:5][CH2:6][O:7][CH2:8][c:9]1[cH:10][cH:11][c:12]([O:13][CH2:14][CH:15]([CH2:16][NH:20][CH2:21][CH2:22][CH2:23][O:24][c:25]2[c:26]([Cl:38])[cH:27][c:28]([C:31]3=[N:36][NH:35][C:34](=[O:37])[CH2:33][CH2:32]3)[cH:29][cH:30]2)[OH:17])[cH:18][cH:19]1

Participants

3

Reactant 2

HCID 150163656-[4-(3-aminopropoxy)-3-chloro-phenyl]-4,5-dihydro-3(2H)-pyridazinoneHCID 151078092-((4-((2-(1-Methylethoxy)ethoxy)methyl)phenoxy)methyl)oxirane

Product 1

HCID 148844226-[4-[3-[3-(4-(2-Isopropoxyethoxy-methyl)phenoxy)-2-hydroxypropylamino]propoxy]-3-chloro-phenyl]-4,5-dihydro-3(2H)-pyridazinone

Sources & evidence

ORD record
ord-449559ab71864acab274a26a0a4dcfd2
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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