Hydrochloric Acid → HCID 67713711, compound

Participants

Reaction Steps

1.32, g (0.0035 mol) of 8-fluoro-5-methyl-3-(5-pyrrolidin-1-ylmethyl-1,2,4-oxadiazol-3-yl)-5,6-dihydro-4H-imidazo [1,5-a][1,4]benzodiazepin-6-one were dissolved in 50 ml of hot ethanol. 0.8 ml (0.0038 mol) of 4.78N ethanolic hydrochloric acid was added at room temperature. The solution was concentrated to a volume of ~20 ml, whereby crystallization began. 80 ml of ether were added, the mixture was filtered and there were obtained 1.38 g (96%) of 8-fluoro-5-methyl-3-(5-pyrrolidin-1-ylmethyl-1,2,4-oxadiazol-3-yl)-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodia-zepin-6-one hydrochloride (1:1) as white crystals; m.p. 243°-245° (dec.).

Provenance & Evidence