Dipropylamine → HCID 54508587, compound

Participants

Reaction Steps

A suspension of 1.30 g (3.33 mmol) of (S)-8-chloro-1-(5-chloromethyl-1,3,4-oxadiazol-2-yl)-11,12,13,13a-tetrahydro-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepin-9-one in 10 ml of N,N-dimethylformamide was treated with 1.7 g (0.017 mol) of dipropylamine. After stirring at room temperature for 20 hrs. and at 80° C. for 4 hrs. the solution obtained was completely freed from the solvents. The residue was chromatographed over silica gel with methylene chloride/methanol 39:1 as the eluent. The product was recrystallized from ether. There were obtained 1.27 g (85%) of (S)-8-chloro-1-(5-dipropylaminomethyl-1,3,4-oxadiazol-2-yl)-11,12,13,13a-tetrahydro-9H-imidazo[1,5-a]pyrrolo[2,1- c][1,4]benzodiazepin-9-one as white crystals; m.p. 158°-160° and [a]D20 =48.8° (CH2Cl2, c=1%).

Provenance & Evidence