Hydrochloric Acid → HCID 70074545, compound

Participants

Reaction Steps

1.27 g (2.79 mmol) of (S)-8-chloro-1-(5-dipropylaminomethyl-1,3,4-oxadiazol-2-yl)-11,1 2,13,13a-tetrahydro-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepin-9-one in 30 ml of ethanol were treated with 0.83 ml (3.07 mmol) of 3.7N ethanolic hydrochloric acid. After stirring at 0° for 15 minutes the solution was treated dropwise with 150 ml of ether and the white suspension obtained was filtered off under suction. There were obtained 1.27 g (93%) of (S)-8-chloro-1-(5-dipropylaminomethyl-1,3,4-oxadiazol-2-yl)-11,1 2,13,13a-tetrahydro-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepin-9-one hydrochloride (1:1) as white crystals; m.p. 204°-206° and [α]D20 =-43.6° (H2O, c=1%).

Provenance & Evidence