Dipropylamine → HCID 22914353, compound

Participants

Reaction Steps

A suspension of 0.193 g (0.51 mmol) of 7-chloro-3-(5-chloromethyl-1,3,4-oxadiazol-2-yl)-8-fluoro-5-methyl-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one in 2 ml of N,N-dimethylformamide was treated with 0.26 g (2.55 mmol) of dipropylamine. After stirring at room temperature for 17 hrs. the solution obtained was completely freed from the solvents. The residue was chromatographed over silica gel with methylene chloride/methanol 39:1 as the eluent. The product was recrystallized from ether/n-hexane at 0°. There were obtained 0.094 g (41%) of 7-chloro-3-(5-dipropylaminomethyl-1,3,4-oxadiazol-2-yl)-8-fluoro-5-methyl-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one as white crystals; m.p. 128°-130°.

Provenance & Evidence