Dipropylamine → HCID 53770728, compound

Participants

Reaction Steps

1.88 g (5 mmol) of (S)-8-chloro-1-(5-chloromethyl-1,3,4-oxadiazol-2-yl)-12,12a-dihydro-9H,11H-azeto[2,1-c]imidazo[1,5-a][1,4]benzodiazepin-9-one were stirred at room temperature over the weekend with 1.12 g (11 mmol) of dipropylamine and 10 ml of N,N-dimethylformamide. After evaporating the reaction mixture the residue was dissolved in methylene chloride and the solution was washed twice with water and dried over magnesium sulfate. After evaporating the solvent and crystallizing the residue from ethyl acetate and hexane there were obtained 2.15 g (98%) of (S)-8-chloro-1-(5-dipropylaminomethyl-1,3,4-oxadiazol-2-yl)-12,12a-dihydro-9H,11H-azeto[2,1-c]imidazo[1,5-a][1,4]benzodiazepin-9-one of m.p. 134°-136°, which was converted into the hydrochloride of melting point 235°-237°.

Provenance & Evidence