HCID 54137505, compound → HCID 53735413, compound

Participants

Reaction Steps

1.8 g (4 mmol) of (S)-1-(3-diallylaminomethyl-1,2,4-oxadiazol-5-yl)-11,12,13,13a-tetrahydro-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepin-9-one were dissolved in 50 ml of methanol and hydrogenated at normal pressure and room temperature in the presence of 60 mg of 5% palladium-charcoal. The catalyst was separated and the solution was evaporated. By chromatography of the residue on silica gel while eluting with methylene chloride/methanol 19.5/0.5 there was obtained 1 g (60%) of (S)-1-(3-dipropylaminomethyl-1,2,4-oxadiazol-5-yl)-11,12,13,13a-tetrahydro-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepin-9-one, which was converted into the hydrochloride of m.p. 198°-201°.

Provenance & Evidence