Pyridine → HCID 54516569, compound

Participants

Reaction Steps

78 g (290 mmol) of (S)-9-oxo-12,12a-dihydro-9H,11H-azeto[2,1-c]imidazo[1,5-a][1,4]benzodiazepine-1-carboxamide were suspended in 380 ml of dioxan and 68 ml of pyridine and treated dropwise at 0° with 59 ml (424 mmol) of trifluoroacetic anhydride. After stirring at 50° for two hours the reaction mixture was poured into 2 l of ice-water and the crystals were filtered off under suction, rinsed with water and dried. There were obtained 60 g (82%) of (S)-9-oxo-12,12a-dihydro-9H,11H-azeto[2,1-c]imidazo[1,5-a][1,4]benzodiazepine-1-carbonitrile of m.p. 232°-234°.

Provenance & Evidence