Sodium Carbonate → HCID 54277862, compound

Participants

Reaction Steps

64.7 g (258 mmol) of (S)-9-oxo-12,12a-dihydro-9H,11H-azeto[2,1-c]imidazo[1,5-a][1,4]benzodiazepine-1-carbonitrile were heated to reflux for 2.5 hours with 52.8 g (497 mmol) of sodium carbonate and 42.36 g (608 mmol) of hydroxylamine hydrochloride in 1.5 l of alcohol and 300 ml of water. The alcohol was evaporated and the suspension obtained was cooled to 0°. The crystals were filtered off under suction, washed with water and dried. There were obtained 68.5 g (93%) of (S)-9-oxo-12,12a-dihydro-9H,11H-azeto[2,1-c]imidazo[1,5-a][1,4]benzodiazepine-1-carboxamidoxime of decomposition point 216°.

Provenance & Evidence