HCID 70076854, compound → HCID 53773985, compound

Participants

Reaction Steps

1.96 g (4.1 mmol) of (S)-1-(5-diallylaminomethyl-1,2,4-oxadiazol-3-yl)-7-fluoro-11,1 2,13,13a-tetrahydro-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]-benzodiazepin-9-one were dissolved in 25 ml of ethyl acetate and hydrogenated at normal pressure and room temperature in the presence of 37 mg of 5% palladium-charcoal. The catalyst was separated and the solution was evaporated. By chromatography of the residue on silica gel while eluting with ethyl acetate there were obtained 1.49 g (83%) of (S)-1-(5-dipropylaminomethyl-1,2,4-oxadiazol-3-yl)-7-fluoro-11,12,13, 13a-tetrahydro-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepin-9-one, which was converted into the hydrochloride of m.p. 222°-225°.

Provenance & Evidence