Water → HCID 22914489, compound

Participants

Reaction Steps

A suspension of 21.5 g (64.1 mmol) of 7-bromo-5-methyl-6-oxo-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxamide in a mixture of 100 ml of dioxan and 15 ml of pyridine was treated at 7° to 10° with 15 ml of trifluoroacetic anhydride. The suspension was stirred at room temperature for 1 hour and poured into 600 ml of water. After 1 hour the suspension was suction filtered. There were obtained 17.8 g (88%) of 7-bromo-5-methyl-6-oxo-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carbonitrile of m.p. 226°-228°.

Provenance & Evidence