Sodium Hydroxide → HCID 9994443, compound

Participants

Reaction Steps

5.4 ml of 5N sodium hydroxide solution were added dropwise to a suspension of 6.9 g (21.6 mmol) of ethyl 8-chloro-5-methyl-6-oxo-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate in 5 ml of ethanol and 7 ml of water and the mixture was heated to reflux for 30 minutes. The solution was filtered while hot, concentrated to about 6 ml and acidified with 5.5 ml 5N hydrochloric acid. The product was filtered off under suction. There were obtained 4.7 g (75%) of 8-chloro-5-methyl-6-oxo-5,6-dihydro-4H-imidazo [1,5-a][1,4]benzodiazepine-3-carboxylic acid as colourless crystals of m.p. 263°-267° (dec.).

Provenance & Evidence