Water → HCID 22914455, compound

Participants

Reaction Steps

1.85 ml (13.4 mmol) of trifluoroacetic anhydride were added dropwise at <8° to a suspension of 3.72 g (12.8 mmol) of 8-chloro-5-methyl-6-oxo-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxamide in 17 ml of dioxan and 2 ml of pyridine. The beige solution obtained was stirred at 50°-60° for 4 hrs., cooled and treated with 80 ml of water. The white crystals were filtered off under suction and dried in a high vacuum. There were obtained 3.08 g (88%) of 8-chloro-5-methyl-6-oxo-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carbonitrile as colourless crystals of m.p. 272°-275°.

Provenance & Evidence