Sodium Hydroxide → HCID 54249109, compound

Participants

Reaction Steps

20.8 g (62.8 mmol) of ethyl (S)-7-chloro-12,12a-dihydro-9-oxo-9H,11H-azeto[2,1-c]imidazo[1,5-a][1,4]benzodiazepine-1-carboxylate in 250 ml of ethanol and 75 ml (75 mmol) of 1N sodium hydroxide solution were heated to reflux for 30 min. The alcohol was evaporated on a rotary evaporator. The residue was dissolved in 250 ml of water and acidified with 1N hydrochloric acid. The crystals were filtered off under suction, washed with water and dried in a vacuum. There were obtained 18.2 g (96%) of (S)-7-chloro-12,12a-dihydro-9-oxo-9H,11H-azeto[2,1-c]imidazo[1,5-a][1,4]benzodiazepine-1-carboxylic acid of m.p. 249°-250° (dec.).

Provenance & Evidence