Methylamine → HCID 22876586, compound

Participants

Reaction Steps

30 ml of methylamine (33% in ethanol) were added dropwise at 70° to a suspension of 2.5 g (5.4 mmol) of (S)-2-[5-(8-oxo-11,11a-dihydro-8H,10H-azeto[1,2-a]imidazo[5,1-c]thieno[3,2-e][1,4]diazepin-1-yl)-1,3,4-oxadiazol-2-ylmethyl]-2,3-dihydro-1H-isoindole-1,3-dione in 30 ml of ethanol and the mixture was stirred at 70° for one hour. The precipitate obtained was filtered off while hot and the yellowish powder obtained was washed colourless with ethanol. There were obtained 1.18 g (66%) of (S)-1-(5-aminomethyl-1,3,4-oxadiazol-2-yl)-11,11a-dihydro-8H,10H-azeto[1,2-a]imidazo[5,1-c]thieno[3,2-e][1,4]-diazepin-8-one as a colourless powder of m.p. 233°-235°.

Provenance & Evidence