Water → HCID 178427874, compound

Participants

Reaction Steps

A solution of 5.5 g of 4-(4-chlorophenyl)-4-ethoxy-1,1,1-trifluoro-3-methyl-3-buten-2-one in 20 mL of MeOH was slowly treated with 0.70 mL of NH2NH2 and allowed to stir for two hours. Water was added to the reaction mixture and a precipitate formed. The solid was collected by filtration and washed with hexanes to yield 3.87 g of 5-(4-chlorophenyl)-4-methyl-3-(trifluoromethyl)-1H-pyrazole as a white powdery product: mp 139.0° C.; 1HNMR (CDCl3) δ 2.09 (s, 3H), 7.39 (m, 2H), 7.45 (m, 2H, 8.5 Hz), 11.75 (bs, 1H). 19FNMR (CDCl3) δ -62.34° (3F). Anal. Calcd for C11H8N2F3Cl: C, 50.69; H, 3,09; N, 10.57. Found: C, 50.68; H, 3.05; N, 10.81.

Provenance & Evidence