1-Benzylpiperazine → 1-[(5-Fluoro-2,3-dihydrobenzofur-2-yl)carbonyl]-4-benzylpiperazine

HRID 1378322Notes

Reaction equation

HRID 1378322 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][CH:8]([C:10]([OH:12])=O)[CH2:7][C:6]=2[CH:13]=1.[CH2:14]([N:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][CH:8]([C:10]([N:24]3[CH2:25][CH2:26][N:21]([CH2:14][C:15]4[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=4)[CH2:22][CH2:23]3)=[O:12])[CH2:7][C:6]=2[CH:13]=1

Participants

3

Reactant 2

HCID 759941-BenzylpiperazineHCID 131024035-Fluoro-2,3-dihydro-1-benzofuran-2-carboxylic acid

Product 1

HCID 214722611-[(5-Fluoro-2,3-dihydrobenzofur-2-yl)carbonyl]-4-benzylpiperazine

Procedure

0.03 mol of 1-[(5-fluoro-2,3-dihydrobenzofur-2-yl)carbonyl]-4-benzylpiperazine (resulting from the condensation of 5-fluoro-2,3-dihydrobenzofuran-2-carboxylic acid with N-benzylpiperazine) is dissolved in 150 ml of anhydrous tetrahydrofuran (T.H.F.). Two times 0.03 mol of lithium aluminum hydride are added in the form of pellets. The mixture is stirred at room temperature. The title compound is obtained.

Sources & evidence

ORD record
ord-8763988ba1ea421c81f0cc77b146919e
Source dataset
uspto-grants-1997_09
Patent number
US05668138

Reaction notes

Loading…