反应详情

0.03 mol of 1-benzylpiperazine, 0.03 mol of 7-methoxy-2-oxo-4-bromomethyl-3-chromene and 0.03 mol of potassium bicarbonate are introduced into an Erlenmeyer flask containing 150 ml of tetrahydrofuran. The mixture is brought to reflux for 24 hours. The reaction is brought to an end and, after cooling, the solution is filtered and evaporated under reduced pressure. The residue is then purified by chromatography on a column of silica gel, methylene chloride generally being used as eluent. The final product is thus obtained in the base form.

1. temperatureto reflux for 24 hours
2. temperatureafter cooling
3. filtrationthe solution is filtered
4. customevaporated under reduced pressure
5. customThe residue is then purified by chromatography on a column of silica gel, methylene chloride