1-Benzylpiperazine → 7-Methoxy-4-{[4-benzylpiperazinyl]methyl}chromen-2-one

HRID 1378324Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1378324
[CH2:1]([N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:14][O:15][C:16]1[CH:25]=[C:24]2[C:19]([C:20]([CH2:27]Br)=[CH:21][C:22](=[O:26])[O:23]2)=[CH:18][CH:17]=1.C(=O)(O)[O-].[K+]>O1CCCC1>[CH3:14][O:15][C:16]1[CH:25]=[C:24]2[C:19]([C:20]([CH2:27][N:11]3[CH2:12][CH2:13][N:8]([CH2:1][C:2]4[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=4)[CH2:9][CH2:10]3)=[CH:21][C:22](=[O:26])[O:23]2)=[CH:18][CH:17]=1

Komponenten

5

Edukt 3

HCID 759941-BenzylpiperazineHCID 1218944-Bromomethyl-7-methoxycoumarinHCID 516893Potassium Bicarbonate

Produkt 1

HCID 11067487-Methoxy-4-{[4-benzylpiperazinyl]methyl}chromen-2-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

0.03 mol of 1-benzylpiperazine, 0.03 mol of 7-methoxy-2-oxo-4-bromomethyl-3-chromene and 0.03 mol of potassium bicarbonate are introduced into an Erlenmeyer flask containing 150 ml of tetrahydrofuran. The mixture is brought to reflux for 24 hours. The reaction is brought to an end and, after cooling, the solution is filtered and evaporated under reduced pressure. The residue is then purified by chromatography on a column of silica gel, methylene chloride generally being used as eluent. The final product is thus obtained in the base form.

Aufarbeitung

  1. temperatureto reflux for 24 hours
  2. temperatureafter cooling
  3. filtrationthe solution is filtered
  4. customevaporated under reduced pressure
  5. customThe residue is then purified by chromatography on a column of silica gel, methylene chloride

Quellen und Nachweise

ORD-Eintrag
ord-5b36025d051f46c293507735243774b2
Quelldatensatz
uspto-grants-1997_09
Patentnummer
US05668138

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