1-Benzylpiperazine → 1-(2-Phenoxy-2-methylpropionyl)-4-benzylpiperazine

HRID 1378329Notes

Reaction equation

HRID 1378329 reaction equation
[O:1]([C:8]([CH3:13])([CH3:12])[C:9](Cl)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:14]([N:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>C(Cl)Cl>[O:1]([C:8]([CH3:13])([CH3:12])[C:9]([N:24]1[CH2:25][CH2:26][N:21]([CH2:14][C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH2:22][CH2:23]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 759941-BenzylpiperazineHCID 131111912-Methyl-2-phenoxypropanoyl chloride

Product 1

HCID 106169921-(2-Phenoxy-2-methylpropionyl)-4-benzylpiperazine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A solution of 0.01 mol of 2-phenoxyisobutyric acid chloride (obtained by reaction of thionyl chloride with 2-phenoxyisobutyric acid) in 100 ml of methylene chloride is introduced into an Erlenmeyer flask containing a solution of 0.01 mol of 1-benzylpiperazine in 100 ml of methylene chloride. The mixture is stirred for 5 hours at room temperature, filtered and evaporated to dryness. The residue is taken up in water, basified and extracted with chloroform. The organic phases are combined, dried and evaporated.

Workup

  1. filtrationfiltered
  2. customevaporated to dryness
  3. extractionextracted with chloroform
  4. customdried
  5. customevaporated

Sources & evidence

ORD record
ord-3bcfaea19aaf46f69f08e67cfa8e5548
Source dataset
uspto-grants-1997_09
Patent number
US05668138

Reaction notes

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