Acetonitrile → HCID 178469282, compound

Participants

Reaction Steps

Combine 5,7-dichloro-quinolin-4-one-2-carboxylic acid, ethyl ester (0.59 g, 2.1 mmol) and benzenesulfonyl isocyanate (0.56 mL, 4.2 mmol) in acetonitrile (10 mL). Heat to reflux under an inert atmosphere. After 16 hours, quench with methanol (5 mL). Evaporate in vacuo. Chromatograph on silica gel eluting with 2% acetone/dichloromethane. Recrystallize from acetonitrile to give the title compound as a solid: TLC Rf =0.31 (silica gel, 2% acetone/dichloromethane); mp; 184°-185° C. Elem. Anal. calculated for C18H14Cl2N2O4S: C, 50.83; H, 3.32; N, 6.59. Found: C, 51.04; H, 3.33; N, 6.56.

Provenance & Evidence