Phenylsulphonyl isocyanate → HCID 178450748, compound

Participants

Reaction Steps

Combine 5,7-dichloro-quinolin-4-one-2-carboxylic acid, butyl ester (1.00 g, 3.2 mmol) and benzenesulfonyl isocyanate (0.85 mL, 6.3 mmol) in acetonitrile (15 mL). Heat to reflux under an inert atmosphere. After 16 hours, quench with methanol (5 mL). Evaporate in vacuo. Chromatograph on silica gel eluting with 2% acetone/dichloromethane. Recrystallize from ethyl acetate/hexane to give the title compound as a solid: TLC Rf =0.38 (silica gel, 2% acetone/dichloromethane); mp; 94°-95° C. Elem. Anal. calculated for C20H18Cl2N2O4S: C, 52.98; H, 4.00; N, 6.18. Found: C, 53.27; H, 3.95; N, 6.12.

Provenance & Evidence