反应详情

Combine chromone-2-carboxylic acid methyl ester (0.341 g, 1.66 mmol) and benzenesulfonyl isocyanate (0.365 g, 1.88 mmol) in acetonitrile (5.0 mL) and reflux. After 24 hours, quench the reaction with methanol (1 mL). Concentrate in vacuo and triturate with hexane. Filter to obtain a paste. Recrystallize the paste from methanol to obtain a solid. Recrystallize from methanol to give the title compound as a solid: mp; 144°-146° C.

1. customquench
2. customthe reaction with methanol (1 mL)
3. concentrationConcentrate in vacuo
4. customtriturate with hexane
5. filtrationFilter
6. customto obtain a paste
7. customRecrystallize the paste from methanol
8. customto obtain a solid
9. customRecrystallize from methanol