Ethanol → HCID 53757515, compound

HRID 1378341Notes

Reaction equation

HRID 1378341 reaction equation
C[O:2][C:3]1[CH:4]=[CH:5][C:6]2[CH2:15][CH2:14][C@H:13]3[C@@H:8]([CH2:9][CH2:10][CH2:11][N:12]3[C:16](=[O:19])[CH2:17][CH3:18])[C:7]=2[CH:20]=1.B(Br)(Br)Br.C(O)C>C(Cl)(Cl)Cl>[OH:2][C:3]1[CH:4]=[CH:5][C:6]2[CH2:15][CH2:14][C@H:13]3[C@@H:8]([CH2:9][CH2:10][CH2:11][N:12]3[C:16](=[O:19])[CH2:17][CH3:18])[C:7]=2[CH:20]=1

Participants

5

Reactant 3

HCID 702EthanolHCID 25134Boron tribromideHCID 22868887HCID 22868887, compound

Product 1

HCID 53757515HCID 53757515, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

A solution of 6.8 g of the compound obtained in Step D in 72 ml of chloroform is cooled to 0° C., then 5.3 ml of boron tribromide are added dropwise thereto. The whole is stirred for 18 hours at room temperature before the addition of 20 ml of ethanol. The resulting precipitate is filtered and washed with water, and 5.1 g of the expected compound are thereby isolated.

Workup

  1. filtrationThe resulting precipitate is filtered
  2. washwashed with water, and 5.1 g of the expected compound
  3. customare thereby isolated

Sources & evidence

ORD record
ord-4e7845b6eaba47a09a4c73aa5e6a528a
Source dataset
uspto-grants-1997_09
Patent number
US05668142

Reaction notes

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