4-(Tetrahydro-2H-pyran-2-yloxy)phenylboronic Acid (contains varying amounts of Anhydride) → HCID 53756881, compound

Participants

Reaction Steps

Using an analogous procedure to that described in Example 1 part (v), but starting from N-(5-chloro-3-methoxypyrazin-2-yl)- N-(isobutoxycarbonyl)-2-iodobenzenesulphonamide and 4-(2-(2H)-tetrahydropyranyloxy)phenylboronic acid, there was obtained in 57% yield N-(5-chloro-3-methoxypyrazin-2-yl)- N-(isobutoxycarbonyl)-4'-[2-(2 H)-tetrahydropyranyloxy]-2-biphenylsulphonamide, m.p. 142°-143° C.; microanalysis found: C, 56.3; H, 5.5; N, 7.1%; C27H30C1N3O7 requires: C, 56.3; H, 5.25; N, 7.3%.

Provenance & Evidence