Cyclohexanemethylamine → HCID 22876920, compound

HRID 1378367Notes

Reaction equation

[CH2:1]([O:3][C:4]([C@H:6]1[NH:8][C@@H:7]1[C:9]([NH:11][C@H:12]([C:20]([OH:22])=O)[CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[O:10])=[O:5])[CH3:2].[CH:23]1([CH2:29][NH2:30])[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]1>>[CH2:1]([O:3][C:4]([C@H:6]1[NH:8][C@@H:7]1[C:9]([NH:11][C@H:12]([C:20]([NH:30][CH2:29][CH:23]1[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]1)=[O:22])[CH2:13][C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1)=[O:10])=[O:5])[CH3:2]

Participants

Reactant 2

HCID 76688Cyclohexanemethylamine

HCID 56994182HCID 56994182, compound

Product 1

HCID 22876920HCID 22876920, compound

Procedure

In substantially the same manner as Working Example 26, Compound 26b (1.22 g) was condensed with cyclohexanemethylamine (0.50 g, manufactured by Wako Pure Chemical Industries, Ltd.) to give the above-titled compound. (Compound 87; 0.85 g) as white crystals (yield 53%).

Sources & evidence

ORD record: ord-577b0296c33b4bada80492b8c540e13b
Source dataset: uspto-grants-1997_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05668128

Reaction notes

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