Phenethylamine → HCID 11035992, compound

Participants

Reaction Steps

In substantially the same manner as Working Example 2, 2-phenylethylamine (4.00 g) was condensed with Boc-L-phenylalanine (7.96 g) to give N-(Boc-L-phenylalanyl)-2-phenylethylamine (9.65 g) (yield 87%). The Boc group of the product was deprotected, in substantially the same manner as Working Example 91, to give N-(L-phenylalanyl)-2-phenylethylamine hydrochloride (4.93 g) (yield 81%). The compound thus obtained (1.00 g) was condensed, in substantially the same manner as Working Example 8, with monoethyl ester of (2S,3S)-N-methylaziridine-2,3-dicarboxylic acid (0.52 g) obtained in Working Example 42 to give the above-titled compound (Compound 93; 1.05 g) as white crystals (yield 83%).

Provenance & Evidence