Benzylamine → (2S)-2-[(tert-butoxy)carbonylamino]-3-(2-naphthyl)-N-benzylpropanamide

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Reaction Steps

In substantially the same manner as Working Example 2, benzylamine (0.93 g) was condensed with Boc-3-(2-naphthyl)-L-alanine (2.50 g) to give N-(Boc-3-(2-naphthyl)-L-alanyl)benzylamine (3.0 g) as white crystals (yield 94%). The Boc group of the product was deprotected by using 4N hydrochloric acid/ethyl acetate solution, and 1.82 g of thus-obtained compound was condensed, in substantially the same manner as Working Example 2, with Compound 1 (1.47 g) to give the above-titled compound (Compound 109; 0.85 g) as white crystals (yield 29%).

Provenance & Evidence