HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 3,5-Dibromo-4-pyridinecarboxaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Lithium diisopropylamide | HCID 2724682 | — |
| Reactant | HCID 178506638 | HCID 178506638 | — |
| Product | 3,5-Dibromo-4-pyridinecarboxaldehyde | HCID 2762998 | — |
Reaction Steps
Following the procedure of Gribble and Saulnier, (Tetrahedron Lett., 21:4137-4140 (1980)) reacting 3,5-bromopyridine (Aldrich) with LDA, and reacting the 3,5-dibromo-4-lithiopyridine with DMF provided 3,5-dibromo-4-pyridinecarboxaldehyde, which was then converted to the title compound by DIBAL reduction. 1H NMR (CDCl3) δ: 8.65 (s, 2H), 4.97 (s, 2H), 2.32 (s, br, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05668141 |
| Source dataset | uspto-grants-1997_09 |
| ORD ID | ord-57e907affccd4c7088bf32ebe6efab63 |
| Source note | uspto-grants-1997_09 |