Diethyl Ether → HCID 86751247, compound

Participants

Reaction Conditions

Reaction Steps

In 2 ml of dichloromethane, is suspended 330 mg (0.606 mmol) of 7-(trans-3-(tertbutoxycarbonylaminomethyl)-4-trifluoromethyl-1-pyrrolidinyl)-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid obtained in Example 10a. To the suspension, is added 2 ml of trifluoroacetic acid on cooling with ice. The mixture is stirred at 0° C. for 1 hour. Diethyl ether was added to the reaction mixture to give a precipitate. The resulting precipitate was obtained by filtration to give 340 mg of the objective substance as a colorless powder (yield 100%).

Provenance & Evidence