HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diphenyl N-Cyanocarbonimidate → N-(5-Amino-6-chloro-3-pyridyl)-N'-cyano-O-phenylisourea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diphenyl N-Cyanocarbonimidate | HCID 688090 | — |
| Reactant | 2-Chloropyridine-3,5-diamine | HCID 22121282 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | N-(5-Amino-6-chloro-3-pyridyl)-N'-cyano-O-phenylisourea | HCID 178512301 | 60.1% |
Reaction Steps
A stirred solution of the product from Step 1 (1.80 g, 0.0125 mol) in ethylene glycol dimethyl ether (DME, 50 ml) was treated with diphenylcyanocarbonimidate (3.0 g, 0.0126 mol) and kept under nitrogen at ambient temperature (25° C.) for 96 hours. The precipitate was collected by filtration, washed with DME and dried to give 2.16 g of the titled product, mp 219°-220° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05668157 |
| Source dataset | uspto-grants-1997_09 |
| ORD ID | ord-53095d2fc189461cabcd0bf533ae3c7c |
| Source note | uspto-grants-1997_09 |