Ethane, 2-bromo-1,1-diethoxy- → HCID 22911704, compound

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Reaction Steps

A mixture of (2-phenoxyphenyl)acetamide (3.9 g) and bromoacetaldehyde diethyl acetal (3.1 ml) in DMF (100 ml) was heated for 2 hours. After cooling, the resulting mixture was diluted with water and extracted with ether. The extracts were washed with water then dried, concentrated and chromatographed using ethyl acetate: hexane (50:50) as eluant to give 2-(2-phenoxyphenylmethyl)oxazole (1.77 g, 41%) as a brown oil, 1H NMR (CDCl3): delta 4.20 (2H,s), 7.01 (1H,s) and 7.54 (1H,s) ppm.

Provenance & Evidence