反应详情

温度

-9 °C

N-[(1,1-dimethylethoxy)carbonyl]cycloleucine (100 g, 0.436 mol) is dissolved in tetrahydrofuran (1.0 L) and the solution is cooled in an ice/salt bath to -9° C. To this is added triethylamine (44.0 g, 0.436 mol) dropwise over a period of 10 minutes. This is followed by the addition of isobutyryl chloroformate (59.6 g, 0.436 mol) over a 15 minute period at which time the temperature rises to -5° C. After stirring for 30 minutes the temperature falls to -13° C. and at that time pulverized L-tyrosine ethyl ester monohydrochloride (107 g, 0.436 mol) is added as a solid in portions. To this suspension is added additional triethylamine (44.0 g, 0.436 mol) over a period of 15 minutes and the temperature rises -3° C. The mixture then is allowed to stir overnight at room temperature. The mixture is then filtered and the filter cake is washed with tetrahydrofuran (1×150 mL). The filtrate is then concentrated in vacuo (50° C., 40 Torr) to approximately 410 g and to this is added tetrahydrofuran (150 mL) for transfer purposes. To this concentrated solution is added heptane (800 mL) and the mixture is stirred overnight at ambient temperature and collected by filtration. The filter cake is washed with t-butyl methyl ether (1×450 mL) and dried at ambient temperature in vacuo (2 Torr) to obtain N-[[1-[[1,1-di-methylethoxy)carbonyl]amino]-1-cyclopentyl]carbonyl]-L-tyrosine ethyl ester, m.p. 162°-165° C.

1. customrises to -5° C
2. customfalls to -13° C. and at that time
3. additionis added as a solid in portions
4. customrises -3° C
5. stirringto stir overnight at room temperature
6. filtrationThe mixture is then filtered
7. washthe filter cake is washed with tetrahydrofuran (1×150 mL)
8. concentrationThe filtrate is then concentrated in vacuo (50° C., 40 Torr) to approximately 410 g
9. additionto this is added tetrahydrofuran (150 mL) for transfer purposes
10. additionTo this concentrated solution is added heptane (800 mL)
11. stirringthe mixture is stirred overnight at ambient temperature
12. filtrationcollected by filtration
13. washThe filter cake is washed with t-butyl methyl ether (1×450 mL)
14. customdried at ambient temperature in vacuo (2 Torr)