HCID 29352885, compound → HCID 178433867, compound

HRID 1378478Notes

Reaction equation

HRID 1378478 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH2:8][NH:9][C:10]([C:12]1[C:13]([CH3:24])=[N:14][N:15]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[C:16]=1Cl)=[O:11].[SH2:25].[Na]>CCOCCO>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH2:8][NH:9][C:10]([C:12]1[C:13]([CH3:24])=[N:14][N:15]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[C:16]=1[SH:25])=[O:11]

Participants

4

Reactant 2

HCID 29352885HCID 29352885, compoundHCID 86586439Sodium hydrogen sulphide

Product 1

HCID 178433867HCID 178433867, compoundYield 81.5%

Reagents, catalysts & solvents 1

HCID 8076Glycol monoethyl etherSolvent

Procedure

Using the procedure of Preparation 34, 29.3 g (0.087 mol) of 5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carboxylic acid (2-pyridin-2-yl-ethyl)-amide was reacted with 19.3 g (0.27 mol) sodium hydrogen sulfide in cellosolve to give 24.0 g of the title compound, which was used in Example 22 without purification.

Sources & evidence

ORD record
ord-be707b3e2dc54ac58b7e98e54f5d0f86
Source dataset
uspto-grants-1997_09
Patent number
US05668162

Reaction notes

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