反应详情

To a solution of 1-(piperidin-4-yl)-indole (100 mg, 0.5 mmol) in absolute ethanol (2 mL) was added anhydrous potassium carbonate (70 mg, 0.5 mmol) and 1-bromo-3-chloropropane (150 mg, 1 mmol). After stirring overnight additional 1-bromo-3-chloropropane (150 mg) was added and stirring continued for 2 hours. The mixture was evaporated; and the residue dissolved in methylene chloride and shaken with water. The organic solution was dried over anhydrous potassium carbonate and evaporated. The residue was chromatographed on silica gel with methylene chloride/ethanol (95:5) to give the title compound (90 mg, 65% yield).

1. additionwas added
2. customThe mixture was evaporated
3. dissolutionand the residue dissolved in methylene chloride
4. stirringshaken with water
5. dry with materialThe organic solution was dried over anhydrous potassium carbonate
6. customevaporated
7. customThe residue was chromatographed on silica gel with methylene chloride/ethanol (95:5)