Sulfuryl chloride → 3-Carbamoyl-4-chloro-5-difluoromethoxy-1-methylpyrazole

HRID 1378663Notes

Reaction equation

HRID 1378663 reaction equation
[C:1]([C:4]1[CH:8]=[C:7]([O:9][CH:10]([F:12])[F:11])[N:6]([CH3:13])[N:5]=1)(=[O:3])[NH2:2].S(Cl)([Cl:17])(=O)=O>C(#N)C>[C:1]([C:4]1[C:8]([Cl:17])=[C:7]([O:9][CH:10]([F:12])[F:11])[N:6]([CH3:13])[N:5]=1)(=[O:3])[NH2:2]

Participants

4

Reactant 2

HCID 24648Sulfuryl chlorideHCID 537319905-(difluoromethoxy)-1-methyl-1H-pyrazole-3-carboxamide

Product 1

HCID 229128043-Carbamoyl-4-chloro-5-difluoromethoxy-1-methylpyrazole

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

23,6 g (0.12 mole) 3-Carbamoyl-5-difluoromethoxy-1-methylpyrazole in 720 ml acetonitrile was treated with 16.7 g (0.12 mole) sulfuryl chloride and the mixture stirred for 10 minutes at room temperature. It was then concentrated and recrystallised from diisopropyl ether/ethyl acetate.

Workup

  1. concentrationIt was then concentrated
  2. customrecrystallised from diisopropyl ether/ethyl acetate

Sources & evidence

ORD record
ord-0b524655bad64125b68e827784466e0a
Source dataset
uspto-grants-1997_09
Patent number
US05668278

Reaction notes

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