HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Ethoxymethylene)propanedinitrile → 5-Amino-1-(3-chloro-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-2-yl)-1h-pyrazole-4-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Ethoxymethylene)propanedinitrile | HCID 67152 | — |
| Reactant | 3-Chloro-2-hydrazino-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine | HCID 54548748 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-Amino-1-(3-chloro-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-2-yl)-1h-pyrazole-4-carbonitrile | HCID 15376433 | — |
Reaction Steps
1.1 g (5.92 mmole) 3-Chloro-2-hydrazino-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine and 0.72 g (5.92 mmole) ethoxymethylenemalononitrile in 10 ml ethanol was heated at reflux for 2 hours. The resulting precipitate was suction filtered, washed with ethanol, dried and purified by silica gel column chromatography (hexane/ethyl acetate).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05668278 |
| Source dataset | uspto-grants-1997_09 |
| ORD ID | ord-fb967d5ddbdb424a956d3f923dffde6d |
| Source note | uspto-grants-1997_09 |