Sodium Bicarbonate → HCID 20726135, compound

Participants

Reaction Steps

Methylamine hydrochloride (0.46 g) and palladium on carbon (0.20 g) were added to a methanol-methylene chloride solution (20-20 ml) of 2.00 g of the (S)-N-{3-[3-fluoro-4-(4-oxo-piperidin-1-yl)-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide (Compound No. 7) which was synthesized in Example 3, and the mixture was stirred at room temperature for 14 h under 2 atm hydrogen atmosphere. Sodium hydrogencarbonate was added and the mixture was stirred for 10 min. Thereafter, the catalyst was filtered off and the solvent was evaporated under vacuum. The residue was purified by alumina column chromatography (solvent: chloroform/methanol=100/1-30/1) to afford the title compound (900 mg) in a yield of 43%.

Provenance & Evidence