Theophylline → HCID 131720202, compound

Participants

Reaction Steps

The activation of theophylline was accomplished by dissolving theophylline-butylate (10 mg; MW 280.29; 3.57×10-5 moles) in methylene chloride (3.0 ml). A three mole excess of dicyclohexyl-carbodiimide (22 mg; MW 206.3) and a three mole excess of N-hydroxysuccinimide (12.3 mg; MW 115.09) were added, and the reaction mixture was stirred over night at room temperature. The mixture was filtered to remove dicyclohexylurea and was rotavaporated to dryness to yield ten milligrams of N-succinimidyl-theophylline-butylate (theophylline-butylate-oSu).

Provenance & Evidence