3-Acetyl-1,2-thiazole-4-carboxylic acid → HCID 178465625, compound

HRID 1378911Notes

Reaction equation

HRID 1378911 reaction equation
[C:1]([C:4]1[C:8]([C:9]([OH:11])=[O:10])=[CH:7][S:6][N:5]=1)(=O)[CH3:2].[F:12][C:13]1[CH:14]=[C:15]([NH:19][C:20]([NH:22][NH2:23])=[NH:21])[CH:16]=[CH:17][CH:18]=1>>[CH3:2][C:1]([C:4]1[C:8]([C:9]([OH:11])=[O:10])=[CH:7][S:6][N:5]=1)=[N:23][NH:22][C:20](=[NH:21])[NH:19][C:15]1[CH:16]=[CH:17][CH:18]=[C:13]([F:12])[CH:14]=1

Participants

3

Reactant 2

HCID 229086823-Acetyl-1,2-thiazole-4-carboxylic acidHCID 178513136HCID 178513136, compound

Product 1

HCID 178465625HCID 178465625, compound

Procedure

Following the procedure of Example 7, 3-acetyl-4-isothiazole carboxylic acid (2.05 g, 12.0 mmol) and N-(3-fluorophenyl)hydrazinecarboximidamide (3.55 g, 12.0 mmol) are reacted together to give 2-[methyl(4-carboxy-3-isothiazolyl)methylene]-N-(3-fluorophenyl)hydrazinecarboximidamide, (compound 17).

Workup

  1. customare reacted together

Sources & evidence

ORD record
ord-342b9e4491734731a4a3969298129eab
Source dataset
uspto-grants-1997_09
Patent number
US05670456

Reaction notes

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