HuagongsheHuagongshe Chemistry Print Report · For research reference only
Selenium Dioxide → Ethyl 2-formylnicotinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Selenium Dioxide | HCID 24007 | — |
| Reactant | Ethyl 2-methylnicotinate | HCID 74401 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | Ethyl 2-formylnicotinate | HCID 15639417 | — |
Reaction Steps
16.9 g of 2-methylnicotinic acid ethyl ester, 22.9 g of selenium (IV) oxide and 240 ml dioxane are combined and refluxed overnight under nitrogen. The mixture is cooled to RT, filtered Through celite, and evaporated. The resulting red sludge is diluted with ethylacetate, filtered twice through celite and the solvent removed by evaporation under vacuum.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05670456 |
| Source dataset | uspto-grants-1997_09 |
| ORD ID | ord-7c43b47781964e58b572aa6e0618f25c |
| Source note | uspto-grants-1997_09 |