Sulfuric Acid → HCID 131719371, compound

Participants

Reaction Steps

6.6 g of 2-(1,2-diethoxycarbonyl-1,2,3,6-tetrahydropyridazin-3-yl)nicotinic acid ethyl ester are mixed with 15 ml water and 60 ml of H2SO4 added with cooling. The reaction mixture is heated under nitrogen to 120° over 1 hr in a hot oil bath. The mixture is slowly poured into 125 g Na2CO3 and 250 g of ice and 125 ml of water. The alkaline mixture is filtered through celite and repeatedly extracted with ethylacetate (8×100 ml) and the extracts dried over MgSO4. After filtration the solvent is removed by evaporation under vacuum to yield the title compound which is recrystalized from CH3CN.

Provenance & Evidence