Diethyl Ether → N,N'-Dicyclohexylurea

Participants

Reaction Steps

Compound 47 (0.45 g., 0.83 mmole) is dissolved in tetrahydrofuran (5 ml.) and 2-methylpropan-1-ol (0.07 g., 0.99 mmole), dimethylaminopyridine (50 mg.), and dicyclohexylcarbodiimide (0.205 g., 0.99 mmole ) are added. The mixture is stirred for three hours. Ether (15 ml.) and hexane (5 ml.) are added. The dicylohexylurea formed is filtered off and the solvent is evaporated. The residual oil is purified by chromatography on silica using 2% methanol in ethyl acetate as eluant, to give Compound 48.

Provenance & Evidence