Ammonia → HCID 22909000, compound

HRID 1378984Notes

Reaction equation

HRID 1378984 reaction equation
[CH3:1][N:2]1[C:10]2[C:9](=[O:11])[N:8]([CH2:12][CH2:13][CH3:14])[C:7](=[O:15])[N:6]([CH2:16][CH2:17][CH3:18])[C:5]=2[N:4]=[C:3]1/[CH:19]=[CH:20]/[C:21]1[C:22]([S:33]([OH:36])(=O)=[O:34])=[C:23]([O:31][CH3:32])[C:24]([O:29][CH3:30])=[C:25]([O:27][CH3:28])[CH:26]=1.[NH3:37]>>[CH3:1][N:2]1[C:10]2[C:9](=[O:11])[N:8]([CH2:12][CH2:13][CH3:14])[C:7](=[O:15])[N:6]([CH2:16][CH2:17][CH3:18])[C:5]=2[N:4]=[C:3]1/[CH:19]=[CH:20]/[C:21]1[C:22]([S:33]([NH2:37])(=[O:36])=[O:34])=[C:23]([O:31][CH3:32])[C:24]([O:29][CH3:30])=[C:25]([O:27][CH3:28])[CH:26]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 22908977HCID 22908977, compound

Product 1

HCID 22909000HCID 22909000, compoundYield 11%

Procedure

Substantially the same procedure as in Example 2 was repeated using 1.80 g (3.45 mmol) of Compound 11 obtained in Example 10 and 1.0 ml of conc. aqueous ammonia. The resulting crude crystals were recrystallized from acetonitrile to give 200 mg (yield 11%) of Compound 12 as yellow needles.

Workup

  1. customThe resulting crude crystals were recrystallized from acetonitrile

Sources & evidence

ORD record
ord-f4a268398db345d980e2ea20a6c64637
Source dataset
uspto-grants-1997_09
Patent number
US05670498

Reaction notes

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