Ethanolamine → HCID 22908982, compound

HRID 1378985Notes

Reaction equation

HRID 1378985 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([S:31](O)(=[O:33])=[O:32])[C:6](=[CH:27][C:28]=1[O:29][CH3:30])/[CH:7]=[CH:8]/[C:9]1[N:17]([CH3:18])[C:16]2[C:15](=[O:19])[N:14]([CH2:20][CH2:21][CH3:22])[C:13](=[O:23])[N:12]([CH2:24][CH2:25][CH3:26])[C:11]=2[N:10]=1.[CH2:35]([CH2:37][NH2:38])[OH:36]>>[OH:36][CH2:35][CH2:37][NH:38][S:31]([C:5]1[C:6](=[CH:27][C:28]([O:29][CH3:30])=[C:3]([O:2][CH3:1])[CH:4]=1)/[CH:7]=[CH:8]/[C:9]1[N:17]([CH3:18])[C:16]2[C:15](=[O:19])[N:14]([CH2:20][CH2:21][CH3:22])[C:13](=[O:23])[N:12]([CH2:24][CH2:25][CH3:26])[C:11]=2[N:10]=1)(=[O:33])=[O:32]

Participants

3

Reactant 2

HCID 700EthanolamineHCID 22909004HCID 22909004, compound

Product 1

HCID 22908982HCID 22908982, compoundYield 57.2%

Procedure

Substantially the same procedure as in Example 2 was repeated using 1.00 g (1.96 mmol) of Compound 1 obtained in Example 1 and 1.2 ml (20.3 mmol) of ethanolamine. The resulting crude crystals were recrystallized from toluene to give 600 mg (yield 55%) of Compound 14 as yellow plates.

Workup

  1. customThe resulting crude crystals were recrystallized from toluene

Sources & evidence

ORD record
ord-3d56327aaab64fb68c3d8ee096a712d8
Source dataset
uspto-grants-1997_09
Patent number
US05670498

Reaction notes

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