Ammonia → (E)-beta-(1,3-Diethyl-7-methylxanthin-8-yl)-5-methoxystyrene-2-sulfonamide

Participants

Reaction Steps

Substantially the same procedure as in Example 2 was repeated using 1.00 g (2.30 mmol) of Compound 16 obtained in Example 15 and 0.7 ml of conc. aqueous ammonia. The resulting crude crystals were purified by high performance liquid chromatography (column: YMC-pack, SH-365-10, 30 i.d.×500 mm, eluent: 40% acetonitrile/water, flow rate: 40 ml/min) to give 55 mg (yield 6%) of Compound 17 as a pale yellow powder.

Provenance & Evidence