Lithium hydroxide, monohydrate → HCID 70046769, compound

Participants

Reaction Steps

Compound 8 (2.64 g, 6.44 mmol) obtained in Example 7 was dissolved in a solvent mixture of 60 ml of dioxane and 40 ml of water. To the solution was added 1.08 g (25.8 mmol) of lithium hydroxide monohydrate, and the resulting mixture was stirred at room temperature for one hour. After neutralization with 1N HCl, the mixture was extracted three times with ethyl acetate. The combined extract was dried over anhydrous sodium sulfate, followed by evaporation under reduced pressure. The resulting crude crystals were recrystallized from toluene/cyclohexane to give 2.26 g (yield 89%) of Compound 18 as a yellow powder.

Provenance & Evidence