Ethyl isocyanate → HCID 136395919, compound

HRID 1379028Notes

Reaction equation

HRID 1379028 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:16]([C:17]3[CH:22]=[CH:21][N:20]=[CH:19][CH:18]=3)=[C:11]3[NH:12][NH:13][CH2:14][CH2:15][N:10]3[N:9]=2)=[CH:4][CH:3]=1.[CH2:23]([N:25]=[C:26]=[O:27])[CH3:24]>ClCCl>[CH2:23]([NH:25][C:26]([N:13]1[CH2:14][CH2:15][N:10]2[N:9]=[C:8]([C:5]3[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=3)[C:16]([C:17]3[CH:22]=[CH:21][N:20]=[CH:19][CH:18]=3)=[C:11]2[NH:12]1)=[O:27])[CH3:24]

Participants

4

Reactant 2

HCID 8022Ethyl isocyanateHCID 135554955HCID 135554955, compound

Product 1

HCID 136395919HCID 136395919, compoundYield 82%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of 7-(4-fluorophenyl)-8-(pyridin-4-yl)-1,2,3,4-tetrahydropyrazolo[5,1-c][1,2,4]triazine (118 mg) and ethyl isocyanate (30 mg) in dichloromethane (2 ml) was stirred at ambient temperature for 1 hour. The mixture was concentrated in vacuo and the residue was crystallized from ethyl acetate to give 2-ethylcarbamoyl-7-(4-fluorophenyl)-8-(pyridin-4-yl)-1,2,3,4-tetrahydropyrazolo[5,1-c][1,2,4]triazine (120 mg).

Workup

  1. concentrationThe mixture was concentrated in vacuo
  2. customthe residue was crystallized from ethyl acetate

Sources & evidence

ORD record
ord-55c1fe46e65f4daf9ba10c3989040f6a
Source dataset
uspto-grants-1997_09
Patent number
US05670503

Reaction notes

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