Sodium Hydroxide → HCID 70110969, compound

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Reaction Steps

A mixture of 2-acetoxyacetyl-7-(4-fluorophenyl)-8-(pyridin-4-yl)-1,2,3,4-tetrahydropyrazolo[5,1-c][1,2,4]triazine (75 mg, 0.190 mmol) and an aqueous sodium hydroxide solution (1N, 0.38 ml, 0.380 mmol) in ethanol (1.5 ml) was stirred for 30 minutes at ambient temperature. After dilution of an aqueous saturated ammonium chloride solution, the mixture was extracted with ethyl acetate. The extracts were dried over sodium sulfate, and concentrated in vacuo. The residue was purified by chromatography on silica gel (eluent:dichloromethane/methanol; 50/1~10/1), and the obtained amorphous product was crystallized from diisopropyl ether to give 7-(4-fluorophenyl)- 2-hydroxyacetyl-8-(pyridin-4-yl)-1,2,3,4-tetrahydropyrazolo[5,1-c][1,2,4]triazine (20 mg).

Provenance & Evidence